What is the form of anemia caused by a dysfunction of hematopoietic tissue?

Primary anemia refers to anemia that arises directly from an intrinsic issue in the hematopoietic tissue, such as the bone marrow, which is responsible for producing blood cells. This dysfunction may be due to various conditions, including aplastic anemia, myelodysplastic syndromes, or leukemia, where the production or functionality of red blood cells, white blood cells, or platelets is impaired. As a result, the body's ability to produce adequate, functional blood cells is compromised, leading to anemia.

Other forms of anemia, such as secondary anemia, are typically due to external factors or other existing diseases influencing red blood cell production but do not primarily originate from a direct impairment of the hematopoietic tissue itself. Iron-deficiency anemia specifically results from a lack of iron, which is a nutritional deficiency rather than a dysfunction of the hematopoietic tissue. Similarly, pernicious anemia stems from an inability to absorb vitamin B12 due to a lack of intrinsic factor but is also not classified as a primary dysfunction of the hematopoietic tissue.